In a Q & A article in the New York Times titled ‘Pain Medications Can Lose Their Punch’, the question was asked: Why would a pain medication lose its efficiency after working well for several years?
In his response Dr Shahil Ahmed, a pain medicine specialist at New York-Presbyterian Hospital / Weill Cornell Medical Center, replied: ‘ It is due to a phenomenon called tolerance., in which there is a decrease in response over time to repeated exposures of the body to pain medication. ‘This might be due to drug interactions, or bodily changes add a substance that induces an enzyme responsible for disposing of the drug.’ Other causes include increase in nervous system receptors, called NMDA receptors.
Dr Ahmed’s practice and research include several alternatives to conventional drug treatment for pain, including use of radio frequency to interrupt the nerve pathways of pain.
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